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Golgi α-mannosidase II cleaves two sugars sequentially in the same catalytic site
Golgi α-mannosidase II (GMII) is a key glycosyl hydrolase in the N-linked glycosylation pathway. It catalyzes the removal of two different mannosyl linkages of GlcNAcMan(5)GlcNAc(2), which is the committed step in complex N-glycan synthesis. Inhibition of this enzyme has shown promise in certain can...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2474516/ https://ncbi.nlm.nih.gov/pubmed/18599462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802206105 |
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