The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFα2 transcription factor

Targeting of gene regulatory factors to specific intranuclear sites may be critical for the accurate control of gene expression. The acute myelogenous leukemia 8;21 (AML1/ETO) fusion protein is encoded by a rearranged gene created by the ETO chromosomal translocation. This protein lacks the nuclear...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	McNeil, Sandra, Zeng, Congmei, Harrington, Kimberly S., Hiebert, Scott, Lian, Jane B., Stein, Janet L., van Wijnen, André J., Stein, Gary S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24742/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10611307/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.26.14882
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