The t(8;21) chromosomal translocation in acute myelogenous leukemia modifies intranuclear targeting of the AML1/CBFα2 transcription factor

Targeting of gene regulatory factors to specific intranuclear sites may be critical for the accurate control of gene expression. The acute myelogenous leukemia 8;21 (AML1/ETO) fusion protein is encoded by a rearranged gene created by the ETO chromosomal translocation. This protein lacks the nuclear...

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Autors principals: McNeil, Sandra, Zeng, Congmei, Harrington, Kimberly S., Hiebert, Scott, Lian, Jane B., Stein, Janet L., van Wijnen, André J., Stein, Gary S.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC24742/
https://ncbi.nlm.nih.gov/pubmed/10611307
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