Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation

The second messengers cAMP and cGMP can be degraded by specific members of the phosphodiesterase superfamily or by active efflux transporters, namely the multidrug resistance-associated proteins (MRPs) MRP4 and MRP5. To determine the role of MRP4 and MRP5 in cell signaling, we studied arterial SMCs,...

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Hauptverfasser: Sassi, Yassine, Lipskaia, Larissa, Vandecasteele, Grégoire, Nikolaev, Viacheslav O., Hatem, Stéphane N., Cohen Aubart, Fleur, Russel, Frans G., Mougenot, Nathalie, Vrignaud, Cédric, Lechat, Philippe, Lompré, Anne-Marie, Hulot, Jean-Sébastien
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2467383/
https://ncbi.nlm.nih.gov/pubmed/18636120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35067
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