Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation

The second messengers cAMP and cGMP can be degraded by specific members of the phosphodiesterase superfamily or by active efflux transporters, namely the multidrug resistance-associated proteins (MRPs) MRP4 and MRP5. To determine the role of MRP4 and MRP5 in cell signaling, we studied arterial SMCs,...

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Detalhes bibliográficos
Main Authors: Sassi, Yassine, Lipskaia, Larissa, Vandecasteele, Grégoire, Nikolaev, Viacheslav O., Hatem, Stéphane N., Cohen Aubart, Fleur, Russel, Frans G., Mougenot, Nathalie, Vrignaud, Cédric, Lechat, Philippe, Lompré, Anne-Marie, Hulot, Jean-Sébastien
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2467383/
https://ncbi.nlm.nih.gov/pubmed/18636120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35067
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