A local electrostatic change is the cause of the large-scale protein conformation shift in bacteriorhodopsin

During light-driven proton transport bacteriorhodopsin shuttles between two protein conformations. A large-scale structural change similar to that in the photochemical cycle is produced in the D85N mutant upon raising the pH, even without illumination. We report here that (i) the pK(a) values for th...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Brown, Leonid S., Kamikubo, Hironari, Zimányi, László, Kataoka, Mikio, Tokunaga, Fumio, Verdegem, Peter, Lugtenburg, Johan, Lanyi, Janos K.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24627/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9144186/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.10.5040
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