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E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor β through E2F binding sites

Transforming growth factor β (TGF-β) causes growth arrest in most cell types. TGF-β induces hypophosphorylation of retinoblastoma susceptibility gene 1 product (RB), which sequesters E2F factors needed for progression into S phase of the cell cycle, thereby leading to cell cycle arrest at G(1). It i...

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Main Authors: Li, Jian-Ming, Hu, Patrick Pei-chih, Shen, Xing, Yu, Yong, Wang, Xiao-Fan
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences of the USA 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC24611/
https://ncbi.nlm.nih.gov/pubmed/9144170
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