Dynamic compression counteracts IL-1β induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs

BACKGROUND: Nitric oxide and prostaglandin E(2 )(PGE(2)play pivotal roles in both the pathogenesis of osteoarthritis and catabolic processes in articular cartilage. These mediators are influenced by both IL-1β and mechanical loading, and involve alterations in the inducible nitric oxide synthase (iN...

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Autori principali: Chowdhury, TT, Arghandawi, S, Brand, J, Akanji, OO, Bader, DL, Salter, DM, Lee, DA
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453754/
https://ncbi.nlm.nih.gov/pubmed/18348730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2389
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