Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

Phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P(2)] is a signaling phospholipid implicated in a wide variety of cellular functions. At synapses, where normal PtdIns(4,5)P(2) balance is required for proper neurotransmission, the phosphoinositide phosphatase synaptojanin 1 is a key regulator of it...

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Detalhes bibliográficos
Main Authors: Voronov, Sergey V., Frere, Samuel G., Giovedi, Silvia, Pollina, Elizabeth A., Borel, Christelle, Zhang, Hong, Schmidt, Cecilia, Akeson, Ellen C., Wenk, Markus R., Cimasoni, Laurent, Arancio, Ottavio, Davisson, Muriel T., Antonarakis, Stylianos E., Gardiner, Katheleen, De Camilli, Pietro, Di Paolo, Gilbert
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453748/
https://ncbi.nlm.nih.gov/pubmed/18591654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803756105
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