MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function

Learning and memory depend on the activity-dependent structural plasticity of synapses and changes in neuronal gene expression. We show that deletion of the MEF2C transcription factor in the CNS of mice impairs hippocampal-dependent learning and memory. Unexpectedly, these behavioral changes were ac...

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Detalhes bibliográficos
Main Authors: Barbosa, Ana C., Kim, Mi-Sung, Ertunc, Mert, Adachi, Megumi, Nelson, Erika D., McAnally, John, Richardson, James A., Kavalali, Ege T., Monteggia, Lisa M., Bassel-Duby, Rhonda, Olson, Eric N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453723/
https://ncbi.nlm.nih.gov/pubmed/18599438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802679105
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