CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis

CD73 is a cell surface enzyme of the purine catabolic pathway that catalyzes the breakdown of AMP to adenosine. Because of the strong immunosuppressive and antiinflammatory properties of adenosine, we predicted that cd73(−/−) mice would develop severe experimental autoimmune encephalomyelitis (EAE),...

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Autores principales: Mills, Jeffrey H., Thompson, Linda F., Mueller, Cynthia, Waickman, Adam T., Jalkanen, Sirpa, Niemela, Jussi, Airas, Laura, Bynoe, Margaret S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2008
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453691/
https://ncbi.nlm.nih.gov/pubmed/18591671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711175105
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