Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion : A New Mechanism for Fat-Induced Impairment of β-Cell Function

OBJECTIVE—Fructose-1,6-bisphosphatase (FBPase) is a gluconeogenic enzyme that is upregulated in islets or pancreatic β-cell lines exposed to high fat. However, whether specific β-cell upregulation of FBPase can impair insulin secretory function is not known. The objective of this study therefore is...

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Detalhes bibliográficos
Main Authors: Kebede, Melkam, Favaloro, Jenny, Gunton, Jenny E., Laybutt, D. Ross, Shaw, Margaret, Wong, Nicole, Fam, Barbara C., Aston-Mourney, Kathryn, Rantzau, Christian, Zulli, Anthony, Proietto, Joseph, Andrikopoulos, Sofianos
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2008
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453625/
https://ncbi.nlm.nih.gov/pubmed/18375435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db07-1326
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