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Liver Autoimmunity Triggered by Microbial Activation of Natural Killer T Cells

Humans with primary biliary cirrhosis (PBC), a disease characterized by the destruction of small bile ducts, exhibit signature autoantibodies against mitochondrial Pyruvate Dehydrogenase Complex E2 (PDC-E2) that crossreact onto the homologous enzyme of Novosphingobium aromaticivorans, an ubiquitous...

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Detalhes bibliográficos
Main Authors: Mattner, Jochen, Savage, Paul B., Leung, Patrick, Oertelt, Sabine S., Wang, Vivien, Trivedi, Omita, Scanlon, Seth T., Pendem, Krishna, Teyton, Luc, Hart, John, Ridgway, William M., Wicker, Linda S., Gershwin, M. Eric, Bendelac, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453520/
https://ncbi.nlm.nih.gov/pubmed/18474357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.03.009
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