Interference with gene regulation in living sea urchin embryos: Transcription factor Knock Out (TKO), a genetically controlled vector for blockade of specific transcription factors

“TKO” is an expression vector that knocks out the activity of a transcription factor in vivo under genetic control. We describe a successful test of this concept that used a sea urchin transcription factor of known function, P3A2, as the target. The TKO cassette employs modular cis-regulatory elemen...

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I whakaputaina i:	Proc Natl Acad Sci U S A
Ngā kaituhi matua:	Bogarad, Leonard D., Arnone, Maria I., Chang, Chieh, Davidson, Eric H.
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	National Academy of Sciences 1998
Ngā marau:	Biological Sciences
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24534/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9843974/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.25.14827
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