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iTRAQ Analysis of Complex Proteome Alterations in 3xTgAD Alzheimer's Mice: Understanding the Interface between Physiology and Disease

Alzheimer's disease (AD) is characterized by progressive cognitive impairment associated with accumulation of amyloid β-peptide, synaptic degeneration and the death of neurons in the hippocampus, and temporal, parietal and frontal lobes of the cerebral cortex. Analysis of postmortem brain tissu...

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Hlavní autoři: Martin, Bronwen, Brenneman, Randall, Becker, Kevin G., Gucek, Marjan, Cole, Robert N., Maudsley, Stuart
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453232/
https://ncbi.nlm.nih.gov/pubmed/18648646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002750
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