A genome-wide RNAi screen for Wnt/β-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer

The Wnt family of secreted proteins coordinate cell fate decision-making in a broad range of developmental and homeostatic contexts. Corruption of Wnt signal transduction pathways frequently results in degenerative diseases and cancer. We have used an iterative genome-wide screening strategy that em...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tang, Wei, Dodge, Michael, Gundapaneni, Deepika, Michnoff, Carolyn, Roth, Michael, Lum, Lawrence
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453074/
https://ncbi.nlm.nih.gov/pubmed/18621708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804709105
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