Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients

The impact of KRAS mutations on cetuximab sensitivity in epidermal growth factor receptor fluorescence in situ hybridisation-positive (EGFR FISH+) metastatic colorectal cancer patients (mCRC) has not been previously investigated. In the present study, we analysed KRAS, BRAF, PI3KCA, MET, and IGF1R i...

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Detalhes bibliográficos
Main Authors: Cappuzzo, F, Varella-Garcia, M, Finocchiaro, G, Skokan, M, Gajapathy, S, Carnaghi, C, Rimassa, L, Rossi, E, Ligorio, C, Di Tommaso, L, Holmes, A J, Toschi, L, Tallini, G, Destro, A, Roncalli, M, Santoro, A, Jänne, P A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2453041/
https://ncbi.nlm.nih.gov/pubmed/18577988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604439
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