Identification of protein–protein interfaces by decreased amide proton solvent accessibility

Matrix-assisted laser desorption ionization–time-of-flight mass spectrometry was used to identify peptic fragments from protein complexes that retained deuterium under hydrogen exchange conditions due to decreased solvent accessibility at the interface of the complex. Short deuteration times allowed...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Mandell, Jeffrey G., Falick, Arnold M., Komives, Elizabeth A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1998
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24513/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9843953/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.25.14705
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