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BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine.

A series of dipyridodiazepinones have been shown to be potent inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. The lead compound, BI-RG-587, had a 50% inhibitory concentration of 84 nM against HIV-1 reverse transcriptase activity. This compound reduced plaque formatio...

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Tallennettuna:
Julkaisussa:Antimicrob Agents Chemother
Päätekijät: Richman, D, Rosenthal, A S, Skoog, M, Eckner, R J, Chou, T C, Sabo, J P, Merluzzi, V J
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 1991
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC244996/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1708976/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.2.305
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