The Immune Response to Herpes Simplex Virus Type 1 Infection in Susceptible Mice Is a Major Cause of Central Nervous System Pathology Resulting in Fatal Encephalitis

This study was undertaken to investigate possible immune mechanisms in fatal herpes simplex virus type 1 (HSV-1) encephalitis (HSE) after HSV-1 corneal inoculation. Susceptible 129S6 (129) but not resistant C57BL/6 (B6) mice developed intense focal inflammatory brain stem lesions of primarily F4/80(...

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Bibliografiske detaljer
Main Authors: Lundberg, Patric, Ramakrishna, Chandran, Brown, Jeffrey, Tyszka, J. Michael, Hamamura, Mark, Hinton, David R., Kovats, Susan, Nalcioglu, Orhan, Weinberg, Kenneth, Openshaw, Harry, Cantin, Edouard M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2446972/
https://ncbi.nlm.nih.gov/pubmed/18480436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00619-08
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