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Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Aβ1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer disease
BACKGROUND: One of the pathological hallmarks of Alzheimer disease (AD) is deposits of amyloid β-peptide (Aβ) in neuritic plaques and cerebral vessels. Immunization of AD mouse models with Aβ reduces Aβ deposits and improves memory and learning deficits. Because recent clinical trials of immunizatio...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2007
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2446608/ https://ncbi.nlm.nih.gov/pubmed/17219449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.993 |
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