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Identification of an early T cell progenitor for a pathway of T cell maturation in the bone marrow

We have identified a rare (≈0.05–0.1%) population of cells (Thy-1(hi)CD16(+)CD44(hi)CD2(−)TCRαβ(−)B220(−)Mac-1(−)NK1.1(−)) in the adult mouse bone marrow that generates CD4(+) and CD8(+) TCRαβ(+) T cells after tissue culture for 48 hr in the presence of Ly5 congenic marrow cells. The essential stage...

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Autori principali: Dejbakhsh-Jones, Sussan, Strober, Samuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC24464/
https://ncbi.nlm.nih.gov/pubmed/10588733
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