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Changes in the Plasmodial Surface Anion Channel Reduce Leupeptin Uptake and Can Confer Drug Resistance in Plasmodium falciparum-Infected Erythrocytes

Cysteine protease inhibitors kill malaria parasites and are being pursued for development as antimalarial agents. Because they have multiple targets within bloodstream-stage parasites, workers have assumed that resistance to these inhibitors would not be acquired easily. In the present study, we use...

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Detalhes bibliográficos
Main Authors: Lisk, Godfrey, Pain, Margaret, Gluzman, Ilya Y., Kambhampati, Shivkumar, Furuya, Tetsuya, Su, Xin-zhuan, Fay, Michael P., Goldberg, Daniel E., Desai, Sanjay A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443925/
https://ncbi.nlm.nih.gov/pubmed/18443109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00057-08
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