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MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

Mutations in the gene encoding the transcriptional repressor methyl-CpG binding protein 2 (MeCP2) cause the neurodevelopmental disorder Rett syndrome. Loss of function as well as increased dosage of MECP2 gene cause a host of neuropsychiatric disorders. To explore the molecular mechanism(s) underlyi...

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Detalhes bibliográficos
Principais autores: Chahrour, Maria, Jung, Sung Yun, Shaw, Chad, Zhou, Xiaobo, Wong, Stephen T. C., Qin, Jun, Zoghbi, Huda Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443785/
https://ncbi.nlm.nih.gov/pubmed/18511691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1153252
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