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The mechanism of pseudouridine synthase I as deduced from its interaction with 5-fluorouracil-tRNA

tRNA pseudouridine synthase I (ΨSI) catalyzes the conversion of uridine to Ψ at positions 38, 39, and/or 40 in the anticodon loop of tRNAs. ΨSI forms a covalent adduct with 5-fluorouracil (FUra)-tRNA (tRNA(Phe) containing FUra in place of Ura) to form a putative analog of a steady-state intermediate...

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Bibliografiska uppgifter
Huvudupphovsmän: Gu, Xiangrong, Liu, Yaoquan, Santi, Daniel V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 1999
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC24426/
https://ncbi.nlm.nih.gov/pubmed/10588695
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