Notch signaling activation in human embryonic stem cells is required for embryonic but not trophoblastic lineage commitment

The Notch signaling pathway plays important roles in cell fate determination during embryonic development and adult life. In this study, we focus on the role of Notch signaling in governing cell fate choices in human embryonic stem (hES) cells. Using genetic and pharmacological approaches, we achiev...

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Main Authors: Yu, Xiaobing, Zou, Jizhong, Ye, Zhaohui, Hammond, Holly, Chen, Guibin, Tokunaga, Akinori, Mali, Prashant, Li, Yue-Ming, Civin, Curt, Gaiano, Nicholas, Cheng, Linzhao
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442567/
https://ncbi.nlm.nih.gov/pubmed/18462696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2008.03.001
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