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FK506-Binding Protein 51 Regulates Nuclear Transport of the Glucocorticoid Receptor β and Glucocorticoid Responsiveness

PURPOSE: A spliced variant of the human glucocorticoid receptor GRβ has been implicated in glucocorticoid responsiveness in glaucoma. Over-expression of the FK506-binding immunophilin FKBP51 also causes a generalized state of glucocorticoid resistance. In the present study, the roles of FKBP51 in th...

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Detalhes bibliográficos
Main Authors: Zhang, Xinyu, Clark, Abbot F., Yorio, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442563/
https://ncbi.nlm.nih.gov/pubmed/18326728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.07-1279
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