Discovery of TBC1D1 as an Insulin-, AICAR-, and Contraction-stimulated Signaling Nexus in Mouse Skeletal Muscle

The Akt substrate of 160 kDa (AS160) is phosphorylated on Akt substrate (PAS) motifs in response to insulin and contraction in skeletal muscle, regulating glucose uptake. Here we discovered a dissociation between AS160 protein expression and apparent AS160 PAS phosphorylation among soleus, tibialis...

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Detalhes bibliográficos
Main Authors: Taylor, Eric B., An, Ding, Kramer, Henning F., Yu, Haiyan, Fujii, Nobuharu L., Roeckl, Katja S. C., Bowles, Nicole, Hirshman, Michael F., Xie, Jianxin, Feener, Edward P., Goodyear, Laurie J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Metabolism and Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442306/
https://ncbi.nlm.nih.gov/pubmed/18276596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708839200
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