Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination

Gross chromosomal rearrangement (GCR) is a type of genomic instability associated with many cancers. In yeast, multiple pathways cooperate to suppress GCR. In a screen for genes that promote GCR, we identified MPH1, which encodes a 3′–5′ DNA helicase. Overexpression of Mph1p in yeast results in decr...

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Main Authors: Banerjee, Soma, Smith, Stephanie, Oum, Ji-Hyun, Liaw, Hung-Jiun, Hwang, Ji-Young, Sikdar, Nilabja, Motegi, Akira, Lee, Sang Eun, Myung, Kyungjae
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2008
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442200/
https://ncbi.nlm.nih.gov/pubmed/18591428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711146
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