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Galpha(s)-coupled receptor signaling actively down-regulates α(4)β(1)-integrin affinity: A possible mechanism for cell de-adhesion
BACKGROUND: Activation of integrins in response to inside-out signaling serves as a basis for leukocyte arrest on endothelium, and migration of immune cells. Integrin-dependent adhesion is controlled by the conformational state of the molecule (i.e. change in the affinity for the ligand and molecula...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2442041/ https://ncbi.nlm.nih.gov/pubmed/18534032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-9-26 |
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