A simple algorithm for quantifying DNA methylation levels on multiple independent CpG sites in bisulfite genomic sequencing electropherograms

DNA methylation at cytosines is a widely studied epigenetic modification. Methylation is commonly detected using bisulfite modification of DNA followed by PCR and additional techniques such as restriction digestion or sequencing. These additional techniques are either laborious, require specialized...

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Bibliografske podrobnosti
Main Authors: Leakey, Tatiana I., Zielinski, Jerzy, Siegfried, Rachel N., Siegel, Eric R., Fan, Chun-Yang, Cooney, Craig A.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2008
Teme:
Methods Online
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441810/
https://ncbi.nlm.nih.gov/pubmed/18480118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn210
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