Protease-activated Receptor-2 Increases Exocytosis via Multiple Signal Transduction Pathways in Pancreatic Duct Epithelial Cells

Protease-activated receptor-2 (PAR-2) is activated when trypsin cleaves its NH(2) terminus to expose a tethered ligand. We previously demonstrated that PAR-2 activates ion channels in pancreatic duct epithelial cells (PDEC). Using real-time optical fluorescent probes, cyan fluorescence protein-Epac1...

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Detalhes bibliográficos
Main Authors: Kim, Mean-Hwan, Choi, Bo-Hwa, Jung, Seung-Ryoung, Sernka, Thomas J., Kim, Seunghwan, Kim, Kyong-Tai, Hille, Bertil, Nguyen, Toan D., Koh, Duk-Su
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2441557/
https://ncbi.nlm.nih.gov/pubmed/18448425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801655200
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