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Mechanism of Signal Propagation upon Retinal Isomerization: Insights from Molecular Dynamics Simulations of Rhodopsin Restrained by Normal Modes

As one of the best studied members of the pharmaceutically relevant family of G-protein-coupled receptors, rhodopsin serves as a prototype for understanding the mechanism of G-protein-coupled receptor activation. Here, we aim at exploring functionally relevant conformational changes and signal trans...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Isin, Basak, Schulten, Klaus, Tajkhorshid, Emad, Bahar, Ivet
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440475/
https://ncbi.nlm.nih.gov/pubmed/18390613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.120691
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