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Mechanism of Signal Propagation upon Retinal Isomerization: Insights from Molecular Dynamics Simulations of Rhodopsin Restrained by Normal Modes

As one of the best studied members of the pharmaceutically relevant family of G-protein-coupled receptors, rhodopsin serves as a prototype for understanding the mechanism of G-protein-coupled receptor activation. Here, we aim at exploring functionally relevant conformational changes and signal trans...

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Detalles Bibliográficos
Main Authors: Isin, Basak, Schulten, Klaus, Tajkhorshid, Emad, Bahar, Ivet
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440475/
https://ncbi.nlm.nih.gov/pubmed/18390613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.120691
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