Genetic Basis of Virulence Attenuation Revealed by Comparative Genomic Analysis of Mycobacterium tuberculosis Strain H37Ra versus H37Rv

Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading infectious disease despite the availability of chemotherapy and BCG vaccine. The commonly used avirulent M. tuberculosis strain H37Ra was derived from virulent strain H37 in 1935 but the basis of virulence attenuation has remained...

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Autori principali: Zheng, Huajun, Lu, Liangdong, Wang, Bofei, Pu, Shiying, Zhang, Xianglin, Zhu, Genfeng, Shi, Wanliang, Zhang, Lu, Wang, Honghai, Wang, Shengyue, Zhao, Guoping, Zhang, Ying
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2440308/
https://ncbi.nlm.nih.gov/pubmed/18584054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002375
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