Effects of MiRP1 and DPP6 β-subunits on the blockade induced by flecainide of K(V)4.3/KChIP2 channels

BACKGROUND AND PURPOSE: The human cardiac transient outward potassium current (I(to)) is believed to be composed of the pore-forming K(V)4.3 α-subunit, coassembled with modulatory β-subunits as KChIP2, MiRP1 and DPP6 proteins. β-Subunits can alter the pharmacological response of I(to); therefore, we...

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Detalhes bibliográficos
Principais autores: Radicke, S, Vaquero, M, Caballero, R, Gómez, R, Núñez, L, Tamargo, J, Ravens, U, Wettwer, E, Delpón, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2439850/
https://ncbi.nlm.nih.gov/pubmed/18536731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.134
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