Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces β(3)-adrenoceptor-mediated relaxation, causing rat detrusor overactivity

BACKGROUND AND PURPOSE: Overactive bladder is a complex and widely prevalent condition, but little is known about its physiopathology. We have carried out morphological, biochemical and functional assays to investigate the effects of long-term nitric oxide (NO) deficiency on muscarinic receptor and...

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Bibliografske podrobnosti
Main Authors: Mónica, F Z T, Bricola, A A O, Báu, F R, Freitas, L L Lopes, Teixeira, S A, Muscará, M N, Abdalla, F M F, Porto, C S, De Nucci, G, Zanesco, A, Antunes, E
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2008
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2438257/
https://ncbi.nlm.nih.gov/pubmed/18297104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.39
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