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Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway

Background and purpose: Rhein, an anthraquinone compound isolated from rhubarb, has been proved effective in treatment of experimental diabetic nephropathy (DN). To explore the mechanism of its therapeutic effect on DN, rhein was tested for its effect on the hexosamine pathway. Experimental approach...

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Detalhes bibliográficos
Main Authors: Zheng, J-M, Zhu, J-M, Li, L-S, Liu, Z-H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2437903/
https://ncbi.nlm.nih.gov/pubmed/18264122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.26
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