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Probing the presence of the ligand-binding haem in cellular nitric oxide receptors
BACKGROUND AND PURPOSE: Nitric oxide (NO) acts on receptors coupled to guanylyl cyclase (GC), leading to cGMP accumulation. The NO binding site is a haem group, oxidation or loss of which diminishes NO-stimulated activity. Agonists reportedly engaging both these NO-insensitive forms have emerged. He...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2437902/ https://ncbi.nlm.nih.gov/pubmed/18204474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707687 |
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