Allosteric Inhibition of the nonMyristoylated c-Abl Tyrosine Kinase by Phosphopeptides Derived from Abi1/Hssh3bp1

Here we report c-Abl kinase inhibition mediated by a phosphotyrosine located in trans in the c-Abl substrate, Abi1. The mechanism, which is pertinent to the nonmyristoylated c-Abl kinase, involves high affinity concurrent binding of the phosphotyrosine pY213 to the Abl SH2 domain and binding of a pr...

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Autors principals: Xiong, Xiaoling, Cui, Ping, Hossain, Sajjad, Xu, Rong, Warner, Brian, Guo, Xinhua, An, Xiuli, Debnath, Asim K., Cowburn, David, Kotula, Leszek
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2435598/
https://ncbi.nlm.nih.gov/pubmed/18328268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2008.01.028
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