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Essential CDK1 inhibitory role for separase during meiosis I in vertebrate oocytes
Separase not only triggers anaphase of meiosis I by proteolytic cleavage of cohesin on chromosome arms; in vitro vertebrate separase also acts as a direct inhibitor of cyclin-dependent kinase 1 (Cdk1) upon liberation from inhibitory securin. Blocking separase-Cdk1 complex formation by microinjection...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2435240/ https://ncbi.nlm.nih.gov/pubmed/16906143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1467 |
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