Compromised CD4(+) CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

CD4(+) CD25(high) regulatory T cells (Tregs) of patients with relapsing-remitting (RR) multiple sclerosis (MS), in contrast to those of patients with secondary progressive (SP) MS, show a reduced suppressive function. In this study, we analysed forkhead box P3 (FOXP3) at the single-cell level in MS...

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Main Authors: Venken, Koen, Hellings, Niels, Thewissen, Marielle, Somers, Veerle, Hensen, Karen, Rummens, Jean-Luc, Medaer, Robert, Hupperts, Raymond, Stinissen, Piet
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2433271/
https://ncbi.nlm.nih.gov/pubmed/17897326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2007.02690.x
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