Use of a sparse sampling study design to assess transfer of tramadol and its O-desmethyl metabolite into transitional breast milk

AIMS: To investigate the transfer of rac-tramadol and its rac-O-desmethyl metabolite into transitional milk, and assess unwanted effects in the breastfed infant. METHODS: Tramadol HCl (100 mg six hourly) was administered to 75 breastfeeding mothers for postoperative analgesia on days 2–4 after Caesa...

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Hlavní autoři: Ilett, Kenneth F, Paech, Michael J, Page-Sharp, Madhu, Sy, Sherwin K, Kristensen, Judith H, Goy, Raymond, Chua, Sebastian, Christmas, Tracey, Scott, Karen L
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2008
Témata:
Clinical Pharmacology in Pregnancy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2432475/
https://ncbi.nlm.nih.gov/pubmed/18294329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03117.x
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