An optimized ibuprofen dosing scheme for preterm neonates with patent ductus arteriosus, based on a population pharmacokinetic and pharmacodynamic study

AIMS: To describe ibuprofen pharmacokinetics in preterm neonates with patent ductus arteriosus (PDA) and to establish relationships between doses, plasma concentrations and ibuprofen efficacy and safety. METHODS: Sixty-six neonates were treated with median daily doses of 10, 5 and 5 mg kg(−1) of ibu...

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Detalhes bibliográficos
Main Authors: Hirt, Déborah, Van Overmeire, Bart, Treluyer, Jean-Marc, Langhendries, Jean-Paul, Marguglio, Arnaud, Eisinger, Mark J, Schepens, Paul, Urien, Saïk
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Pharmacodynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2432471/
https://ncbi.nlm.nih.gov/pubmed/18307541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03118.x
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