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DNA-DEPENDENT CONFORMATIONAL CHANGES IN THE KU HETERODIMER
Ionizing radiation induces DNA double-strand breaks which are repaired by the non-homologous end joining (NHEJ) pathway. NHEJ is initiated upon Ku binding to the DNA ends and facilitating an interaction with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). This heterotrimeric DNA-PK co...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2432109/ https://ncbi.nlm.nih.gov/pubmed/18355052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi702284c |
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