An Amphipathic Helical Region of the N-terminal Barrel of Phospholipid Transfer Protein Is Critical for ABCA1-dependent Cholesterol Efflux

Phospholipid lipid transfer protein (PLTP) mimics high-density lipoprotein apolipoproteins in removing cholesterol and phospholipids from cells through the ATP-binding cassette transporter A1 (ABCA1). Because amphipathic α-helices are the structural determinants for ABCA1 interactions, we examined t...

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Main Authors: Oram, John F., Wolfbauer, Gertrud, Tang, Chongren, Davidson, W. Sean, Albers, John J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431062/
https://ncbi.nlm.nih.gov/pubmed/18287097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800117200
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