Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition

BACKGROUND: Recent evidence suggests that oxytocin (OT), secreted in the superficial spinal cord dorsal horn by descending axons of paraventricular hypothalamic nucleus (PVN) neurons, produces antinociception and analgesia. The spinal mechanism of OT is, however, still unclear and requires further i...

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Autors principals: Breton, Jean-Didier, Veinante, Pierre, Uhl-Bronner, Sandra, Vergnano, Angela Maria, Freund-Mercier, Marie José, Schlichter, Rémy, Poisbeau, Pierrick
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2008
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430948/
https://ncbi.nlm.nih.gov/pubmed/18510735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-4-19
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