A Randomized Controlled Phase IIb Trial of Antigen-Antibody Immunogenic Complex Therapeutic Vaccine in Chronic Hepatitis B Patients

BACKGROUND: The safety of the immune complexes composed of yeast-derived hepatitis B surface antigen (HBsAg) and antibodies (abbreviated as YIC) among healthy adults and chronic hepatitis B patients has been proved in phase I and phase IIa trial. A larger number of patients for study of dosage and e...

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Main Authors: Xu, Dao-Zhen, Zhao, Kai, Guo, Li-Min, Chen, Xin-Yue, Wang, Hui-Fen, Zhang, Ji-Ming, Xie, Qin, Ren, Hong, Wang, Wen-Xiang, Li, Lan-Juan, Xu, Min, Liu, Pei, Niu, Jun-Qi, Bai, Xue-Fan, Shen, Xin-Liang, Yuan, Zheng-Hong, Wang, Xuan-Yi, Wen, Yu-Mei
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430617/
https://ncbi.nlm.nih.gov/pubmed/18596958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002565
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