Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin

Neutrophil granulocytes form the body’s first line of antibacterial defense, but they also contribute to tissue injury and noninfectious, chronic inflammation. Proteinase 3 (PR3) and neutrophil elastase (NE) are 2 abundant neutrophil serine proteases implicated in antimicrobial defense with overlapp...

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Detalhes bibliográficos
Main Authors: Kessenbrock, Kai, Fröhlich, Leopold, Sixt, Michael, Lämmermann, Tim, Pfister, Heiko, Bateman, Andrew, Belaaouaj, Azzaq, Ring, Johannes, Ollert, Markus, Fässler, Reinhard, Jenne, Dieter E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430496/
https://ncbi.nlm.nih.gov/pubmed/18568075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34694
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