Secondary anchor substitutions in an HLA-A*0201-restricted T-cell epitope derived from Her-2/neu

We investigated analogues of GP2 (IISAVVGIL), an HLA-A*0201-restricted T-cell epitope derived from residues 654−662 in the tumor-associated antigen (TAA) Her-2/neu. One limiting factor of GP2 is its poor affinity for HLA-A*0201. Conformational analysis revealed the P5–P7 region in GP2 appears to be...

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Detalhes bibliográficos
Main Authors: Joseph, Matthew A., Mitchell, Megan L., Evanseck, Jeffrey D., Kovacs, Jeffrey R., Jia, Liang, Shen, Hongmei, Meng, Wilson S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2430429/
https://ncbi.nlm.nih.gov/pubmed/16597462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2006.02.027
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