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Evaluation of influenza virus mutants for possible use in a live virus vaccine
Two approaches to the attenuation of influenza A2 virus were studied: adaptation to a sub-optimum growth temperature and the production of temperature-sensitive mutants. A strain of A2/Hong Kong/68 virus was adapted to growth at 25°C in calf kidney tissue culture, and a virus suspension was prepared...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1969
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2427735/ https://ncbi.nlm.nih.gov/pubmed/5309483 |
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