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Ordered Phosphorylation Governs Oscillation of a Three-Protein Circadian Clock

The simple circadian oscillator found in cyanobacteria can be reconstituted in vitro using three proteins—KaiA, KaiB, and KaiC. The total phosphorylation level of KaiC oscillates with a circadian period, but the mechanism underlying its sustained oscillation remains unclear. We have shown that four...

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Detalhes bibliográficos
Main Authors: Rust, Michael J., Markson, Joseph S., Lane, William S., Fisher, Daniel S., O’Shea, Erin K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427396/
https://ncbi.nlm.nih.gov/pubmed/17916691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1148596
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