Competency for Nonsense-Mediated Reduction in Collagen X mRNA Is Specified by the 3′ UTR and Corresponds to the Position of Mutations in Schmid Metaphyseal Chondrodysplasia

Nonsense-mediated decay (NMD) is a eukaryotic cellular RNA surveillance and quality-control mechanism that degrades mRNA containing premature stop codons (nonsense mutations) that otherwise may exert a deleterious effect by the production of dysfunctional truncated proteins. Collagen X (COL10A1) non...

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Detalhes bibliográficos
Main Authors: Tan, Jacqueline T., Kremer, Friederike, Freddi, Susanna, Bell, Katrina M., Baker, Naomi L., Lamandé, Shireen R., Bateman, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2008
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2427218/
https://ncbi.nlm.nih.gov/pubmed/18304492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2008.01.006
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